Optimizing and Standardizing 129Xe Gas Exchange MRI to Visualize Regional Therapy Response in Interstitial Lung Disease
The purpose of this multi-centered, NIH-sponsored study is to to develop an optimal protocol for using noninvasive 129Xe gas exchange MRI to detect changing disease activity in interstitial lung diseases (ILDs).
• Outpatients of either gender, age greater than or equal to 18 years
• Willing and able to give informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.)
• Subject has no diagnosed pulmonary conditions
• Subject has not smoked in the previous 5 years
• Smoking history, if any, is less than or equal to 5 pack-years
• No history of using other inhaled products more than 1 time per week for \> 1 year
• Outpatients of either gender, age greater than or equal to 18 years
• Willing and able to give informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.)
• Clinical diagnosis of Interstitial Lung Disease made by a board certified pulmonologist using established criteria. We will not exclude individuals based on ILD type or severity of disease with the exception of the below criteria